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The efficacy and safety of pegylated interferon α-2b-based immunotherapy for inactive hepatitis B surface antigen carriers by Huibin Ning; Kuan Li; Zhen Peng; Huiming Jin; Hong Zhao; Jia Shang is a Medicine article available to read on EtoBox.

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## Objectives Pegylated interferon α-2b (PegIFNα-2b) therapy can help inactive hepatitis B surface antigen (HBsAg) carriers (IHCs) achieve clinical cure. To explore and compare the efficacy, safety, and relevant influential factors of PegIFNα-2b monotherapy and PegIFNα-2b-based immunotherapy for IHCs. ## Methods This exploratory, prospective, single-center, randomized controlled trial enrolled 40 IHCs who were randomized into group A (PegIFNα-2b treatment for 68 weeks) and group B (two cycles of PegIFNα-2b treatment with a lead-in period of GM-CSF and vaccine treatment before each cycle). The primary endpoint was 68-week HBsAg loss rate. ## Results At week 68, the HBsAg loss rates were 45.45% [full analysis set (FAS)] and 46.67% [per-protocol set (PPS)]. There was no statistically significant difference in HBsAg loss rate between groups A and B (__P__> 0.05). Univariate analysis revealed that age ≤40 years old, baseline HBsAg <200 IU/ml, and 24-week HBsAg decline ≥2 log~10~ IU/ml were significantly associated with HBsAg loss in FAS population (__P__ < 0.05). Multivariate analysis showed that only 24-week HBsAg decline ≥2 log~10~ IU/ml was the independent influencing factor in both

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Author

Huibin Ning; Kuan Li; Zhen Peng; Huiming Jin; Hong Zhao; Jia Shang

Publisher

Lippincott Williams And Wilkins

Published

2023

Language

EN

Field

Medicine (Health Sciences)