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Can I read A Trial‐based Economic Evaluation of Peppermint Oil for the Treatment of Irritable Bowel Syndrome on EtoBox?
A Trial‐based Economic Evaluation of Peppermint Oil for the Treatment of Irritable Bowel Syndrome by Zsa Zsa R. M. Weerts; Brigitte A. B. Essers; Daisy M. A. E. Jonkers; Jeresa I. A. Willems; Deborah J. P. A. Janssen; Ben J. M. Witteman; Cees H. M. Clemens; Audrey Westendorp; Ad A. M. Masclee; Daniel Keszthelyi is a Medicine article available to read on EtoBox.
What is A Trial‐based Economic Evaluation of Peppermint Oil for the Treatment of Irritable Bowel Syndrome about?
## Abstract ## Background Irritable Bowel Syndrome (IBS) is a prevalent, chronic gastrointestinal disorder that imposes a substantial socioeconomic burden. Peppermint oil is a frequently used treatment for IBS, but evidence about cost‐effectiveness is lacking. ## Objective We aimed to assess cost‐effectiveness of small‐intestinal release peppermint oil versus placebo in IBS patients. ## Methods In a multicenter randomized placebo‐controlled trial, cost‐effectiveness was evaluated from a societal perspective. The incremental cost‐effectiveness ratios (ICERs) were expressed as (1) incremental costs per Quality Adjusted Life Years (QALY), and (2) incremental costs per successfully treated patient, that is per abdominal pain responder (according to FDA definitions), both after an eight‐week treatment period with placebo versus peppermint oil. Cost‐utility and uncertainty were estimated using non‐parametric bootstrapping. Sensitivity analyses were performed. ## Results The analysis comprised 126 patients (__N__ = 64 placebo, __N__ = 62 small‐intestinal release peppermint oil). Peppermint oil was a dominant treatment compared to placebo in 46% of bootstrap replications. Peppermint oil wa
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- Author
- Zsa Zsa R. M. Weerts; Brigitte A. B. Essers; Daisy M. A. E. Jonkers; Jeresa I. A. Willems; Deborah J. P. A. Janssen; Ben J. M. Witteman; Cees H. M. Clemens; Audrey Westendorp; Ad A. M. Masclee; Daniel Keszthelyi
- Publisher
- Wiley
- Published
- 2021
- Language
- EN
- Field
- Medicine (Health Sciences)