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This document discusses the application of Focused Beam Reflectance Measurement (FBRM) in the production of active pharmaceutical ingredients, particularly for in situ particle characterization during crystallization and granulation processes. It presents a mathematical method for optimizing chord length classes from measured chord-length distributions (CLDs) to improve data interpretation, as traditional methods may lack accuracy. The authors analyze a batch crystallization of R-lactose monohydrate and add

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4n4n4s

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EN