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Enhancement and control of acoustic cavitation yield by low-level dual frequency sonication: A subharmonic analysis by Hadi Hasanzadeh; Manijhe Mokhtari-Dizaji; S. Zahra Bathaie; Zuhair M. Hassan; Vahid Nilchiani; H. Goudarzi is a Engineering article available to read on EtoBox.

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Evaluation of inertial cavitation is a significant problem where this mechanism of action is responsible for therapeutic applications such as drug delivery. It has shown that using multiple frequencies one is able to enhance and control induced cavitation. In this study, we used different sonication frequencies as 28 kHz, 130 kHz, 1 MHz, 3 MHz and their dual combinations to enhance acoustic cavitation. At each frequency, two different intensities were used and the subharmonic amplitude of each frequency in combinations was measured. It was observed that in combinations which include 28 kHz, the cavitation activity is enhanced. The 28 kHz subharmonic amplitude was used to compare these protocols in their ability to enhance cavitation. Besides, the area of cavitation damage was determined using an aluminum foil. Our results showed that the inertial cavitation activity increased at higher intensities and there is a significant correlation between the subharmonic amplitude and sonication intensity at each frequency (R>0.90). In addition, simultaneous combined dual-frequency orthogonal sonication at 28 kHz with other frequencies used can significantly increase the inertial cavitation ac

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Author

Hadi Hasanzadeh; Manijhe Mokhtari-Dizaji; S. Zahra Bathaie; Zuhair M. Hassan; Vahid Nilchiani; H. Goudarzi

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 1350-4177)

Published

2011

Language

EN

Field

Engineering (Physical Sciences)