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Synthesis, Characterization and in Vitro Anti-invasive Activity Screening of Polyphenolic and Heterocyclic Compounds by Virinder S Parmar; Nawal K Sharma; Mofazzal Husain; Arthur C Watterson; Jayant Kumar; Lynne A Samuelson; Ashok L Cholli; Ashok K Prasad; Ajay Kumar; Sanjay Malhotra; Naresh Kumar; Amitabh Jha; Amarjit Singh; Ishwar Singh; Himanshu; Archana Vats; Najam A Shakil; Smriti Trikha; Shubasish Mukherjee; Sunil K Sharma; Sanjay K Singh; Ajay Kumar; Hriday N Jha; Carl E Olsen; Christophe P Stove; Marc E Bracke; Marc M Mareel is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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Invasion is the hallmark of malignant tumors, and is responsible for the bad prognosis of the untreated cancer patients. The search for anti-invasive treatments led us to screen compounds of different classes for their effect in an assay for invasion. Thirty-nine new compounds synthesized in the present study along with 56 already reported compounds belonging mainly to the classes of lactones, pyrazoles, isoxazoles, coumarins, desoxybenzoins, aromatic ketones, chalcones, chromans, isoflavanones have been tested against organotypic confronting cultures of invasive human MCF-7/6 mammary carcinoma cells with embryonic chick heart fragments in vitro. Three of them (a pyrazole derivative, an isoxazolylcoumarin and a prenylated desoxybenzoin) inhibited invasion at concentrations as low as 1 microM; instead of occupying and replacing the heart tissue within 8 days, the MCF-7/6 cells grew around the heart fragments and left it intact, when treated with these compounds. At the anti-invasive concentration of 1 microM, the three compounds did not affect the growth of the MCF-7/6 cells, as shown in the sulforhodamine B assay. Aggregate formation on agar was not stimulated by any of the three a

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Author

Virinder S Parmar; Nawal K Sharma; Mofazzal Husain; Arthur C Watterson; Jayant Kumar; Lynne A Samuelson; Ashok L Cholli; Ashok K Prasad; Ajay Kumar; Sanjay Malhotra; Naresh Kumar; Amitabh Jha; Amarjit Singh; Ishwar Singh; Himanshu; Archana Vats; Najam A Shakil; Smriti Trikha; Shubasish Mukherjee; Sunil K Sharma; Sanjay K Singh; Ajay Kumar; Hriday N Jha; Carl E Olsen; Christophe P Stove; Marc E Bracke; Marc M Mareel

Publisher

Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0968-0896)

Published

2003

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)