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Can I read Adolescent Cannabinoid and Nicotine Exposure Differentially Alters Adult Nicotine Self-Administration in Males and Females on EtoBox?
Adolescent Cannabinoid and Nicotine Exposure Differentially Alters Adult Nicotine Self-Administration in Males and Females by Dukes, Angeline J; Fowler, James P; Lallai, Valeria; Pushkin, Anna N; Fowler, Christie D is a Medicine article available to read on EtoBox.
What is Adolescent Cannabinoid and Nicotine Exposure Differentially Alters Adult Nicotine Self-Administration in Males and Females about?
## Abstract ## Introduction During adolescence, exposure to nicotine or cannabis independently induces effects on neuromaturation and later cognitive function. However, the potential effect of both drugs under co-use conditions has become of increasing concern given the prevalence of e-cigarettes, legalization of cannabis, and availability of synthetic “spice” cannabinoid agonists. ## Aims and Methods The current studies investigated the effects of exposure to a cannabinoid receptor agonist (WIN55,212-2) and/or nicotine over a discrete time period in mid-adolescence on later intravenous nicotine self-administration in adult male and female mice. We further examined whether cannabinoid agonist administration in adulthood would alter nicotine reinforcement, with either acute or chronic pairing across 7 days. ## Results We found that adult males exhibited increased nicotine self-administration at a lower, rewarding nicotine dose following adolescent cannabinoid exposure, either alone or with nicotine coadministration. In contrast, adult females demonstrated an opposing effect in which adolescent cannabinoid and nicotine coexposure resulted in decreased nicotine intake compared with th
Who reads Adolescent Cannabinoid and Nicotine Exposure Differentially Alters Adult Nicotine Self-Administration in Males and Females?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Dukes, Angeline J; Fowler, James P; Lallai, Valeria; Pushkin, Anna N; Fowler, Christie D
- Publisher
- Oxford University Press; Oxford University Press (OUP); Informa UK Limited (ISSN 1462-2203)
- Published
- 2020
- Language
- EN
- Field
- Medicine (Health Sciences)