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Characterization of an Early Cytotoxicity-inducing Factor in Sera of Japanese Quails After Inoculation with Rous Sarcoma Virus by Yasuhiro Yoshikawa; Kazuya Yamanouchi; Akiko Fukuda; Masanori Hayami is a Medicine article available to read on EtoBox.

What is Characterization of an Early Cytotoxicity-inducing Factor in Sera of Japanese Quails After Inoculation with Rous Sarcoma Virus about?

## Abstract By pre‐treatment with serum of normal spleen cells used in the microcytotoxicity assay, a humoral factor which induces cytotoxic activity in normal spleen cells was demonstrated in about 40% of sera of Japanese quails as early as 3 days after inoculation with Rous sarcoma virus (RSV). This cytotoxicity‐inducing activity was not present either in the IgM or the IgG fraction obtained by Sephadex gel filtration. In sera of quails with experimentally induced agammaglobulinemia, the cytotoxicity‐inducing activity was demonstrated at the same frequency as in normal animals. Thus, it seems unlikely that the early cytotoxicity‐inducing factor is an immunoglobulin. On the other hand, membrane fractions extracted with 3 m potassium chloride from the RSV‐induced quail tumor (QT) cells used as target cells in the microcytotoxicity assay exhibited cytotoxicity‐inducing activity. After spontaneous regression of an RSV‐induced tumor the serum of the regressor quail contained antibodies specific to the QT cell extract. This serum removed the cytotoxicity‐inducing activity of both QT cell extract and serum sampled 3 days after RSV inoculation. In contrast, serum without antibody to the

Who reads Characterization of an Early Cytotoxicity-inducing Factor in Sera of Japanese Quails After Inoculation with Rous Sarcoma Virus?

Author

Yasuhiro Yoshikawa; Kazuya Yamanouchi; Akiko Fukuda; Masanori Hayami

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square; Test accounts (ISSN 0020-7136)

Published

1976

Language

EN

Field

Medicine (Health Sciences)