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Electrospun aligned nanofibrous composite of MWCNT/polyurethane to enhance vascular endothelium cells proliferation and function by Jie Meng; Zhaozhao Han; Hua Kong; Xiaojin Qi; Chaoying Wang; Sishen Xie; Haiyan Xu is a Engineering article available to read on EtoBox.

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## Abstract Aligned or random nanofibrous meshes of multiwalled carbon nanotubes/polyurethane composite (MWCNT/PU) were fabricated by electrospinning and characterized by scanning electron microscopy (SEM). The regulatory effects of nanofibrous structure and MWCNT on the growth and anticoagulant function of human umbilical vein endothelial cells (HUVECs) were investigated by examining proliferation, type IV collagen secretion, tissue factor and plasminogen activator inhibitor‐1 (PAI‐1) release, and cytoskeleton arrangement, as well as via pull‐down analysis. We show that aligned nanofibrous structure and MWCNT can function as extracellular signals to stimulate cell growth, proliferation, and extracellular collagen secretion, in addition to preserving anticoagulant function. The nanofibrous structures played important roles in the activation of Rac and Cdc42, while CNT regulated the activation of Rho. These two features synergistically activated Rho GTPases that transmitted cell‐substrate signals to the cytoplasm. These signals were then relayed to the nucleus by the MAP kinase pathway to direct cytoskeletal arrangement and cell orientation. © 2010 Wiley Periodicals, Inc. J Biomed M

Who reads Electrospun aligned nanofibrous composite of MWCNT/polyurethane to enhance vascular endothelium cells proliferation and function?

Author

Jie Meng; Zhaozhao Han; Hua Kong; Xiaojin Qi; Chaoying Wang; Sishen Xie; Haiyan Xu

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 1549-3296)

Published

2010

Language

EN

Field

Engineering (Physical Sciences)