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Can I read T cell therapy of human CMV and EBV infection in immunocompromised hosts on EtoBox?
T cell therapy of human CMV and EBV infection in immunocompromised hosts by Stanley R. Riddell; Philip D. Greenberg is a Medicine article available to read on EtoBox.
What is T cell therapy of human CMV and EBV infection in immunocompromised hosts about?
Acute virus infections in normal hosts are typically controlled by the development of a host immune response that includes MHC-restricted virus-specific T cells. Many viruses have developed methods to evade T cell recognition to facilitate initial infection and the establishment of a persistent infection in the host. Human cytomegalovirus (CMV) and Epstein-Barr virus (EBV) are ubiquitous human pathogens that utilise novel strategies to evade immune elimination. Despite these evasion methods, CD4 + and CD8 + T cells expressing T cell receptors have been shown to play a pivotal role in controlling initial infection and in maintaining CMV and EBV in a latent state. However, in settings of iatrogenic or acquired T cell deficiency, primary infection or reactivation of CMV and EBV frequently progresses to cause life threatening disease. In this article the role of MHC-restricted CD8 + and CD4 + T cell responses in controlling CMV and EBV infections in healthy individuals and the development of novel strategies to restore protective T cell immunity to deficient hosts by the adoptive transfer of virus-specific T cells is reviewed. 1997 by
Who reads T cell therapy of human CMV and EBV infection in immunocompromised hosts?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Stanley R. Riddell; Philip D. Greenberg
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 1052-9276)
- Published
- 1997
- Language
- EN
- Field
- Medicine (Health Sciences)