Can I read Molecular organisation of the malate synthase genes of Aspergillus nidulans and Neurospora crassa on EtoBox?

Molecular organisation of the malate synthase genes of Aspergillus nidulans and Neurospora crassa by Ruth A. Sandeman; Michael J. Hynes; John R.S. Fincham; Ian F. Connerton is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Molecular organisation of the malate synthase genes of Aspergillus nidulans and Neurospora crassa about?

The sequencing and comparison of the genes encoding the glyoxylate bypass enzyme malate synthase of Aspergillus nidulans (acuE) and Neurospora crassa (acu-9) are presented. The predicted amino acid sequences of the A. nidulans and N. crassa enzymes are 538 and 542 residues respectively and the proteins are 87% homologous. In fungi, the malate synthase proteins are located in glyoxysomes and the deduced acuE and acu-9 proteins both contain a C-terminal S-K-L sequence, which has been implicated in transport into peroxisomes. The acuE coding region is interrupted by four introns and the acu-9 coding region is interrupted by one intron which occurs at the same position as the C-terminal acuE intron. The 5' non-coding regions of the two genes were examined for short homologous sequences that may represent the binding sites for regulatory proteins. Pyrimidine-rich sequences with weak homology to the amdI9 sequence, which has been implicated in facB-mediated acetate regulation of the amdS gene, were found but their functional significance remains to be determined.

Who reads Molecular organisation of the malate synthase genes of Aspergillus nidulans and Neurospora crassa?

Author

Ruth A. Sandeman; Michael J. Hynes; John R.S. Fincham; Ian F. Connerton

Publisher

Springer; Springer-Verlag; Springer Verlag; Springer Science and Business Media LLC (ISSN 0026-8925)

Published

1991

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)