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Lysophosphatidic Acid-Induced Proliferation-Related Signals in Astrocytes by Jeffrey N. Keller; Marion R. Steiner; Frederick W. Holtsberg; Mark P. Mattson; Sheldon M. Steiner is a Neuroscience article available to read on EtoBox.

What is Lysophosphatidic Acid-Induced Proliferation-Related Signals in Astrocytes about?

Abstract: Lysophosphatidic acid (LPA) is a potent lipid biomediator that is likely to have diverse roles in the brain. Thus, LPA‐induced events in astrocytes were defined. As little as 1 n__M__ LPA induced a rapid increase in the concentration of intracellular free calcium ([Ca^2+^]~i~) in astrocytes from neonatal rat brains. This increase was followed by a slow return to the basal level. Intracellular calcium stores were important for the initial rise in [Ca^2+^]~i~, whereas the influx of extracellular calcium contributed significantly to the extended elevation of [Ca^2+^]~i~. LPA treatment also resulted in increases in lipid peroxidation and DNA synthesis. These increases in [Ca^2+^]~i~, lipid peroxidation, and DNA synthesis were inhibited by pretreatment of cells with pertussis toxin or H7, a serine/threonine protein kinase inhibitor. Moreover, the LPA‐induced increase in [Ca^2+^]~i~ was inhibited by a protein kinase C inhibitor, Ro 31‐8220, and a calcium‐dependent protein kinase C inhibitor, Gö 6976. The increase in [Ca^2+^]~i~ was important for the LPA‐induced increase in lipid peroxidation, whereas the antioxidant, propyl gallate, inhibited the LPA‐stimulated increases in lip

Who reads Lysophosphatidic Acid-Induced Proliferation-Related Signals in Astrocytes?

Author

Jeffrey N. Keller; Marion R. Steiner; Frederick W. Holtsberg; Mark P. Mattson; Sheldon M. Steiner

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0022-3042)

Published

1997

Language

EN

Field

Neuroscience (Life Sciences)