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Double‐blind placebo‐controlled multicentre studies of rebamipide, a gastroprotective drug, in the treatment of functional dyspepsia with or without Helicobacter pylori infection by N. J. Talley; D. S. Riff; H. Schwartz; S. P. Marcuard is a Medicine article available to read on EtoBox.

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## Background: Functional dyspepsia is a problem that is difficult to treat in clinical practice. ## Aim: To evaluate the efficacy and safety of rebamipide (a cytoprotective drug) in functional dyspepsia. ## Methods: Patients with functional dyspepsia (__n__=557) were divided a priori into two studies by __Helicobacter pylori__ status, and enrolled in a 2‐week baseline evaluation period. Ninety‐nine patients with __Helicobacter pylori__ and 173 patients without __Helicobacter pylori__, continuing to have at least moderate upper abdominal pain or discomfort, were randomly assigned to rebamipide 100 mg, rebamipide 200 mg or placebo, three times a day, in a double‐blind design for 8 weeks. ## Results: There was significant improvement of individual symptom scores from baseline in all the treatment arms. No significant improvement of individual symptom scores was observed in either rebamipide group at the end of the studies compared to placebo, although the belching score was significantly reduced in the rebamipide 100 mg and 200 mg groups at week 2 (__P__=0.017 and __P__=0.012, respectively) in the __Helicobacter pylori__‐positive patients. The ratio of patients who requested usage of

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Author

N. J. Talley; D. S. Riff; H. Schwartz; S. P. Marcuard

Publisher

John Wiley and Sons; Blackwell Publishing; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley; Research Square (ISSN 0269-2813)

Published

2001

Language

EN

Field

Medicine (Health Sciences)