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Potentiation of Amygdaloid and Hippocampal Auditory-evoked Potentials in a Discriminatory Fear-conditioning Task in Mice as a Function of Tone Pattern and Context by Jianrong Tang; Stefanie Wagner; Melitta Schachner; Alexander Dityatev; Carsten T. Wotjak is a Neuroscience article available to read on EtoBox.
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## Abstract According to the local memory storage hypothesis, information about the tone–shock association in an auditory fear‐conditioning paradigm is stored in synapses within the lateral amygdala. Thus, fear‐conditioning‐induced potentiation of auditory‐evoked potentials in response to a conditioned stimulus (CS+, a series of short lasting tones; patterned tone) has been interpreted as an __in vivo__ correlate of amygdaloid synaptic plasticity. Here, we re‐examine the specificity of potentiation of auditory‐evoked potentials in terms of (i) local confinement to the lateral amygdala, (ii) parameters of CS+ and (iii) influence of context, using a discriminatory fear‐conditioning paradigm. Adult male C57BL/6J mice were implanted with recording electrodes aimed at the lateral amygdala, the CA1 region of the hippocampus and the neck muscles for simultaneous recordings of auditory‐evoked potentials and startle responses. In a neutral context, auditory‐evoked potentials within lateral amygdala and CA1 as well as startle and freezing responses to the CS+ were significantly potentiated following conditioning, as compared with pre‐conditioning values and responses to a neutral stimulus (C
Who reads Potentiation of Amygdaloid and Hippocampal Auditory-evoked Potentials in a Discriminatory Fear-conditioning Task in Mice as a Function of Tone Pattern and Context?
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- Author
- Jianrong Tang; Stefanie Wagner; Melitta Schachner; Alexander Dityatev; Carsten T. Wotjak
- Publisher
- John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0953-816X)
- Published
- 2003
- Language
- EN
- Field
- Neuroscience (Life Sciences)