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Can I read The Th17/IL-17 Axis and Host Defense Against Fungal Infections on EtoBox?
The Th17/IL-17 Axis and Host Defense Against Fungal Infections by Stuart G. Tangye; Anne Puel is a Medicine article available to read on EtoBox.
What is The Th17/IL-17 Axis and Host Defense Against Fungal Infections about?
Chronic mucocutaneous candidiasis (CMC) was recognized as a primary immunodeficiency in the early 1970’s. However, for almost 40 years, its genetic etiology remained unknown. The progressive molecular and cellular description of inborn errors of immunity (IEI) with syndromic CMC pointed toward a possible role of IL-17-mediated immunity in protecting against fungal infection and CMC. Since 2011, novel IEI affecting either the response to or production of IL-17A and IL-17F (IL-17A/F) in patients with isolated or syndromic CMC provided formal proof of the pivotal role of the IL-17 axis in mucocutaneous immunity to Candida spp. And, to a lesser extent, to Staphylococcus aureus in humans. In contrast, IL-17-mediated immunity seems largely redundant against other common microbes in humans. In this review, we outline the current knowledge of IEI associated with impaired IL-17A/F-mediated immunity, highlighting our current understanding of the role of IL-17A/F in human immunity.
Who reads The Th17/IL-17 Axis and Host Defense Against Fungal Infections?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Stuart G. Tangye; Anne Puel
- Publisher
- Elsevier BV
- Published
- 2023
- Language
- EN
- Field
- Medicine (Health Sciences)