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Activation of the G Protein–Coupled Estrogen Receptor Prevented the Development of Acute Colitis by Protecting the Crypt Cell by Qian Wang; Zhao Li; Kaixuan Liu; Jianbo Liu; Shiquan Chai; Guanyu Chen; Shuyu Wen; Tian Ming; Jiayi Wang; Yuntao Ma; Honghui Zeng; Chuanyong Liu; Bing Xue is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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G protein-coupled estrogen receptor (GPER) might be involved in ulcerative colitis (UC), but the direct effect of GPER on UC is still unclear. We used male C57BL/6 mice to establish the acute colitis model with administration of dextran sulfate sodium and explored the effect of GPER on acute colitis and its possible mechanism. The selective GPER agonist G-1 inhibited weight loss and colon shortening and decreased the disease activity index for colitis and histologic damage in mice with colitis. All of these effects were prevented by a selective GPER blocker. G-1 administration prevented the dysfunction of tight junction protein expression and goblet cells in colitis model and thus inhibited the increase of mucosal permeability in colitis-suffering mice significantly. GPER activation reduced expression of glucose-regulating peptide-78 and anti-CCAAT/enhancer-binding protein homologous protein and attenuated the three arms of the unfolded protein response in colitis. G-1 therapy inhibited the increase of cleavage caspase-3- and TUNEL-positive cells in colonic crypts in the colitis model, increased the number of Ki67- and bromodeoxyuridine-positive cells in crypts, and reversed the de

Who reads Activation of the G Protein–Coupled Estrogen Receptor Prevented the Development of Acute Colitis by Protecting the Crypt Cell?

Author

Qian Wang; Zhao Li; Kaixuan Liu; Jianbo Liu; Shiquan Chai; Guanyu Chen; Shuyu Wen; Tian Ming; Jiayi Wang; Yuntao Ma; Honghui Zeng; Chuanyong Liu; Bing Xue

Publisher

American Society for Pharmacology & Experimental Therapeutics (ASPET)

Published

2020

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)