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Protective Effect of Polydeoxyribonucleotide Against CCl~4~-Induced Acute Liver Injury in Mice by Seunghwan Lee; Kyu Yeoun Won; Sunhyung Joo is a Medicine article available to read on EtoBox.

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Purpose: Polydeoxyribonucleotide (PDRN) is a substance known to suppress inflammation and accelerate wound healing. In this experiment, the effect of PDRN treatment on carbon tetrachloride (CCl~4~)-evoked acute liver injury (ALI) was investigated using mice.Methods: We analyzed the levels of serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) and conducted hematoxylin and eosin staining in accompany with terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling staining. Western blot analysis was also conducted to assess the expressions of tumor necrosis factor (TNF)-α, interleukin (IL)-1β, IL-6, adenosine A~2A~ receptor, Bcl-2-associated X protein (Bax), and B-cell lymphoma 2 (Bcl-2). The mice were received intraperitoneal injection of 10-mL/kg CCl~4~, 4 times, once every 2 days. The mice in the PDRN treatment groups received intraperitoneal injection of 200-μL distilled water comprising each concentration of PDRN for 7 days starting 1 day after first CCl~4~ injection.Results: ALT and AST concentrations in the serum were reduced and TNF-α, IL-1β, and IL-6 expressions were decreased by PDRN injection in CCl~4~-evoked ALI mice. PDRN injection suppre

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Author

Seunghwan Lee; Kyu Yeoun Won; Sunhyung Joo

Publisher

Korean Continence Society

Published

2020

Language

EN

Field

Medicine (Health Sciences)