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Reduced exercise capacity in untreated adults with primary growth hormone resistance (Laron syndrome) by Issahar Ben-Dov; Mark Gaides; Mickey Scheinowitz; Rivka Wagner; Zvi Laron is a Medicine article available to read on EtoBox.

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## Summary **objective** Primary IGF‐I deficiency (Laron syndrome, LS) may decrease exercise capacity as a result of a lack of an IGF‐I effect on heart, peripheral muscle or lung structure and/or function. **methods** Eight patients (six females) who had never received treatment with IGF‐I, with mean age of 36 ± 10 (SD) years (range 21–48), weight 47 ± 9 kg (31–61), height 126 ± 12 cm (112–140) and body mass index of 29 ± 4 kg/m^2^ (24–34), and 12 age‐matched controls, underwent lung function tests and incremental cycling to the limit of tolerance (CPX, MedGraphics). Predicted values for the patients were derived from adult equations based on height. **results** In LS patients, lung function was near normal; vital capacity was 84 ± 11% of expected (66–103). Peak exercise O~2~‐uptake and the anaerobic threshold were reduced, 57 ± 20% of predicted and 33 ± 9% of predicted peak (__P__ = 0·005 __vs.__ controls), despite normal mean exercise breathing reserve. All parameters were normal in the controls. **conclusion** Exercise capacity in untreated adults with LS is significantly reduced. The limitation for most patients was not ventilatory but resulted either from low cardiac output an

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Author

Issahar Ben-Dov; Mark Gaides; Mickey Scheinowitz; Rivka Wagner; Zvi Laron

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley; Research Square (ISSN 0300-0664)

Published

2003

Language

EN

Field

Medicine (Health Sciences)