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Can I read Targeting Notch and EGFR signaling in human mucoepidermoid carcinoma on EtoBox?
Targeting Notch and EGFR signaling in human mucoepidermoid carcinoma by Wei Ni; Zirong Chen; Xin Zhou; Rongqiang Yang; Mu Yu; Jianrong Lu; Frederic J. Kaye; Lizi Wu is a Medicine article available to read on EtoBox.
What is Targeting Notch and EGFR signaling in human mucoepidermoid carcinoma about?
## Abstract Mucoepidermoid carcinoma (MEC) is the most common type of salivary gland cancers and patients with advanced, metastatic, and recurrent MECs have limited therapeutic options and poor treatment outcomes. MEC is commonly associated with a chromosomal translocation t(11;19) (q14-21;p12-13) that encodes the CRTC1-MAML2 oncogenic fusion. The CRTC1-MAML2 fusion is required for MEC growth in part through inducing autocrine AREG-EGFR signaling. Growing evidence suggests that MEC malignancy is maintained by cancer stem-like cells. In this study, we aimed to determine critical signaling for maintaining MEC stem-like cells and the effect of combined targeting of stem cell signaling and CRTC1-MAML2-induced EGFR signaling on blocking MEC growth. First, we evaluated the significance of Notch signaling in regulating MEC stem-like cells. Aberrantly activated Notch signaling was detected in human fusion-positive MEC cells. The inhibition of Notch signaling with genetic or pharmacological inhibitors reduced oncosphere formation and ALDH-bright population in vitro and blocked the growth of MEC xenografts in vivo. Next, we investigated the effect of co-targeting Notch signaling and EGFR sig
Who reads Targeting Notch and EGFR signaling in human mucoepidermoid carcinoma?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Wei Ni; Zirong Chen; Xin Zhou; Rongqiang Yang; Mu Yu; Jianrong Lu; Frederic J. Kaye; Lizi Wu
- Publisher
- Springer Science and Business Media LLC
- Published
- 2021
- Language
- EN
- Field
- Medicine (Life Sciences)