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Preparation, Drug Release and Cellular Uptake of Doxorubicin-loaded Dextran-b-poly(ɛ-caprolactone) Nanoparticles by Bengang Li; Qing Wang; Xin Wang; Chongzhi Wang; Xiqun Jiang is a Materials Science article available to read on EtoBox.

What is Preparation, Drug Release and Cellular Uptake of Doxorubicin-loaded Dextran-b-poly(ɛ-caprolactone) Nanoparticles about?

Amphiphilic dextran-b-poly(ε-caprolactone) diblock copolymers were synthesized with the purpose of preparing nanocarriers for doxorubicin (DOX), an anticancer drug. The Dex-b-PCL diblock copolymers were synthesized by end-to-end coupling of amino-terminated dextran and aldehyde-terminated poly(-caprolactone) and characterized by 1 H NMR spectra and gel permeation chromatography. The DOX-loaded Dex-b-PCL nanoparticles were prepared by a modified nanoprecipitation method and characterized by transmission electron microscopy and dynamic light scattering. In vitro release of DOX from DOX-Dex-b-PCL nanoparticles showed a sustained release manner with certain amount of burst release in the first 9 h. In vitro cytotoxicity test of DOX-Dex-b-PCL nanoparticles against SH-SY5Y cells showed that DOX is still pharmacologically active after drug loading. The fluorescence imaging results showed that DOX-Dex-b-PCL nanoparticles could be easily uptaken by SH-SY5Y cells. These results indicate that DOX-Dex-b-PCL nanoparticles may be a promising nanocarrier for DOX.

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Author

Bengang Li; Qing Wang; Xin Wang; Chongzhi Wang; Xiqun Jiang

Publisher

Elsevier BV

Published

2013

Language

EN

Field

Materials Science (Physical Sciences)