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Can I read Angioimmunoblastic Lymphadenopathy with Dysproteinemia: Emphasis on Pathogenesis and Treatment on EtoBox?
Angioimmunoblastic Lymphadenopathy with Dysproteinemia: Emphasis on Pathogenesis and Treatment by Sabah Sallah; Gregory A. Gagnon is a Medicine article available to read on EtoBox.
What is Angioimmunoblastic Lymphadenopathy with Dysproteinemia: Emphasis on Pathogenesis and Treatment about?
Angioimmunoblastic lymphadenopathy with dysproteinemia (AILD) is a rare lymphoproliferative disorder characterized by diffuse lymphadenopathy, fever, hepatosplenomegaly, hemolytic anemia, and polyclonal hypergammaglobulinemia. Morphologically, the involved lymph nodes demonstrate complete effacement of the normal architecture, prominent neovascularization and infiltration by immunoblasts and plasma cells. Other terms that have been used to describe this entity include diffuse plasmacytic sarcomatosis, immunoblastic lymphadenopathy, lymphogranulomatosis X, and immunologic aberrations in idiopathic reticulosis. Initially, AILD was thought to be a disease of B-cell origin that represented reactive immune response to unknown stimulus and high potential for malignant transformation. It is now evident that AILD in 80% of cases follows an aggressive course with short median survival, especially, if complete response with chemotherapy is not achieved. Immunologic and molecular studies have demonstrated that the majority of AILD cases are T-cell clonal disorders. Despite the numerous reports on the role of Epstein-Barr virus in this disorder, it is unknown whether the presence of this virus
Who reads Angioimmunoblastic Lymphadenopathy with Dysproteinemia: Emphasis on Pathogenesis and Treatment?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Sabah Sallah; Gregory A. Gagnon
- Publisher
- S. Karger AG
- Published
- 1998
- Language
- EN
- Field
- Medicine (Health Sciences)