Can I read Pregabalin in Outpatient Detoxification of Subjects with Mild-to-moderate Alcohol Withdrawal Syndrome on EtoBox?

Pregabalin in Outpatient Detoxification of Subjects with Mild-to-moderate Alcohol Withdrawal Syndrome by M. Di Nicola; G. Martinotti; D. Tedeschi; A. Frustaci; M. Mazza; M. Sarchiapone; G. Pozzi; P. Bria; L. Janiri is a Medicine article available to read on EtoBox.

What is Pregabalin in Outpatient Detoxification of Subjects with Mild-to-moderate Alcohol Withdrawal Syndrome about?

## Abstract ## Objective In this open, prospective study we aimed to investigate the efficacy, medical safety and practicability of pregabalin in outpatient detoxification of alcohol‐dependent patients with mild‐to‐moderate alcohol withdrawal syndrome (AWS). Craving reduction, improvement of psychiatric symptoms and quality of life were the secondary endpoints. ## Methods Forty alcohol dependent patients (DSM‐IV) were detoxified receiving 200–450 mg of pregabalin. Withdrawal (Clinical Institute Withdrawal Assessment for Alcohol (CIWA‐Ar)) and craving (Visual Analogue Scale (VAS); Obsessive and Compulsive Drinking Scale (OCDS)) rating scales were applied; psychiatric symptoms and quality of life were evaluated using the Symptom Check List‐90 Revised (SCL‐90‐R) and the QL‐Index, respectively. Relapsed and abstinent patients in the post‐detoxification evaluation have been compared. ## Results Alcohol withdrawal symptoms and craving for alcohol resulted significantly reduced (__p__ < 0.001) over time after pregabalin treatment. Pregabalin also resulted in a favourable improvement in psychiatric symptoms and quality of life (__p__ < 0.001). ## Conclusions To our knowledge, this is the f

Who reads Pregabalin in Outpatient Detoxification of Subjects with Mild-to-moderate Alcohol Withdrawal Syndrome?

Author

M. Di Nicola; G. Martinotti; D. Tedeschi; A. Frustaci; M. Mazza; M. Sarchiapone; G. Pozzi; P. Bria; L. Janiri

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0885-6222)

Published

2010

Language

EN

Field

Medicine (Health Sciences)