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Regio- and Stereoselective Synthesis of Gem-difluorocyclopropanes Using 4-Bromo-4,4-difluorocrotonate by Takeo Taguchi; Hirofumi Sasaki; Akira Shibuya; Tsutomu Morikawa is a Chemistry article available to read on EtoBox.

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## Regio-and stereoselective formation of the finctionalized gem-dt@orocyclopropane derivative was achieved through the Michael aakiition of lithium enolate of ester or amide with 4bromo-4.4-difluorocrotonate I followed by the triethylborane-02 mediated intramolecular substihction reaction. Cyclopropane derivatives have been recognized as an important class of compounds found in natural and unnatural substances, with particularly significant application in bio-and medicinal chemistry. 12 For example,

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Author

Takeo Taguchi; Hirofumi Sasaki; Akira Shibuya; Tsutomu Morikawa

Publisher

Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0040-4039)

Published

1994

Language

EN

Field

Chemistry (Physical Sciences)