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Comprehensive two-dimensional liquid chromatography: Ion chromatography×reversed-phase liquid chromatography for separation of low-molar-mass organic acids by Stella S. Brudin; Robert A. Shellie; Paul R. Haddad; Peter J. Schoenmakers is a Chemistry article available to read on EtoBox.

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In the work presented here a novel approach to comprehensive two-dimensional liquid chromatography is evaluated. Ion chromatography is chosen for the first-dimension separation and reversed-phase liquid chromatography is chosen for the second-dimension separation mode. The coupling of these modes is made possible by neutralising the first-dimension effluent, containing KOH, prior to transfer to the second-dimension reversed-phase column. A test mixture of 24 low-molar-mass organic acids is used for optimisation of the system. Three food and beverage samples were analysed in order to evaluate the developed methodology, the resulting two-dimensional separation is near-orthogonal, the set-up is simple and all instrumental components are available commercially. The method proved to be robust and suitable for the analysis of wine, orange juice and yogurt.

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Author

Stella S. Brudin; Robert A. Shellie; Paul R. Haddad; Peter J. Schoenmakers

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 1873-3778)

Published

2010

Language

EN

Field

Chemistry (Physical Sciences)