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Mutagenicity and genotoxicity of PM~2.5~ issued from an urbano‐industrialized area of Dunkerque (France) by V. André; S. Billet; D. Pottier; J. Le Goff; I. Pottier; G. Garçon; P. Shirali; F. Sichel is a Environmental Science article available to read on EtoBox.

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## Abstract Epidemiological studies have demonstrated the link between chronic exposure to particulate matter (PM), especially particles with an aerodynamic diameter lesser than 2.5 μm (PM~2.5~), and lung cancer. Mechanistic investigations focus on the contribution of the various genotoxicants adsorbed onto the particles, and more particularly on polycyclic aromatic hydrocarbons or nitroaromatics. Most of the previous studies dealing with genotoxic and/or mutagenic measurements were performed on organic extracts obtained from PM~2.5~ collected in polluted areas. In contrast, we have evaluated genotoxic and mutagenic properties of urbano‐industrial PM~2.5~ (PM) collected in Dunkerque (France). Thermally desorbed PM~2.5~ (dPM) was also comparatively studied. Suspensions of PM and dPM (5–50 μg per plate) were tested in __Salmonella__ tester strains TA98, TA102 and YG1041 ± S9mix. Significant mutagenicity was observed for PM in YG1041 ± S9 mix. In strain TA102 – S9mix, a slight, but not significant dose–response increase was observed, for both PM and dPM. Genotoxic properties of PM and dPM were evaluated by the measurement of (1) 8‐OHdG in A549 cells and (2) bulky DNA adducts on A549 c

Who reads Mutagenicity and genotoxicity of PM~2.5~ issued from an urbano‐industrialized area of Dunkerque (France)?

Author

V. André; S. Billet; D. Pottier; J. Le Goff; I. Pottier; G. Garçon; P. Shirali; F. Sichel

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square (ISSN 0260-437X)

Published

2011

Language

EN

Field

Environmental Science (Physical Sciences)