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Anti‐imm_unoglobulin E antibody treatment blocks histamine release and tissue contraction in sensitized mice by HAAK‐FRENDSCHO; SABAN†; SHIELDS; JARDIEU is a Immunology and Microbiology article available to read on EtoBox.

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Inhibition of antigen‐specific IgE response has been shown to lead to amelioration of allergic disease symptoms. In an effort to design a therapy aimed at decreasing IgE levels, we reported previously that treatment of mice with an anti‐IgE antibody coincident with the primary antigen imm\_unization resulted in significant decreases in antigen‐specific IgE synthesis, without substantially altering IgG levels. In the present study, we employed this mouse model and a surrogate antibody to investigate the capacity of anti‐IgE treatment to block an established IgE response __in vivo__. Results of these experiments suggest that anti‐IgE treatment concomitant with an antigen boost results in removal of detectable circulating IgE for at least 7 weeks (the duration of the study). Moreover, tissues removed from mice following anti‐IgE treatment failed to release histamine and contract in response to antigen challenge __ex vivo__. These findings demonstrate that reduction of circulating IgE correlates to an inhibition of tissue mast cell sensitization and mediator release in response to antigen challenge and further supports the concept of anti‐IgE treatment as a promising therapy for the tr

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Author

HAAK‐FRENDSCHO; SABAN†; SHIELDS; JARDIEU

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0019-2805)

Published

1998

Language

EN

Field

Immunology and Microbiology (Life Sciences)