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Pathologic complete response and overall survival in breast cancer subtypes in stage III inflammatory breast cancer by Dominique J. P. van Uden; Marissa C. van Maaren; Peter Bult; Luc J. A. Strobbe; J. J. M. van der Hoeven; Charlotte F. J. M. Blanken-Peeters; Sabine Siesling; Johannes H. W. de Wilt is a Medicine article available to read on EtoBox.
What is Pathologic complete response and overall survival in breast cancer subtypes in stage III inflammatory breast cancer about?
## Purpose: To analyze the influence of hormone receptors (hr) and human epidermal growth factor receptor-2 (her2)-based molecular subtypes in stage iii inflammatory breast cancer (ibc) on tumor characteristics, treatment, pathologic response to neoadjuvant chemotherapy (nact), and overall survival (os). ## Methods: Patients with stage iii ibc, diagnosed in the netherlands between 2006 and 2015, were classified into four breast cancer subtypes: hr+/her2- , hr+/her2+ , hr-/her2+ , and hr-/her2- . patient-, tumor- and treatment-related characteristics were compared. in case of nact, pathologic complete response (pcr) was compared between subgroups. os of the subtypes was compared using kaplan-meier curves and the log-rank test. ## Results: 1061 patients with stage iii ibc were grouped into subtypes: hr+/her2- (n = 453, 42.7%), hr-/her2- (n = 258, 24.3%), hr-/her2+ (n = 180,17.0%), and hr+/her2+ (n = 170,16.0%). in total, 679 patients (85.0%) received nact. in hr-/her2+ tumors, pcr rate was highest (43%, (p < 0.001). in case of pcr, an improved survival was observed for all subtypes, especially for hr+/her2+ and hr-/her2+ tumor subtypes. trimodality therapy (nact, surgery, radiotherap
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- Author
- Dominique J. P. van Uden; Marissa C. van Maaren; Peter Bult; Luc J. A. Strobbe; J. J. M. van der Hoeven; Charlotte F. J. M. Blanken-Peeters; Sabine Siesling; Johannes H. W. de Wilt
- Publisher
- Springer US; Springer-Verlag; Kluwer Academic Publishers; Springer Science and Business Media LLC (ISSN 0167-6806)
- Published
- 2019
- Language
- EN
- Field
- Medicine (Health Sciences)