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Stimulation of hepatocyte DNA synthesis by prostaglandin E~2~ and prostaglandin F~2~α additivity with the effect of norepinephrine, and synergism with epidermal growth factor by Magne Refsnes; G. Hege Thoresen; Olav F. Dajani; Thoralf Christoffersen is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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## Abstract Previous data obtained in vivo and in vitro suggest that both prostaglandins (PGs) and catecholamines may have a role in promoting hepatocyte proliferation, and PGE~2~ and PGFF~2α~ have also been implicated as mediators of the mitogenic actions of epidermal growth factor (EGF) (and transforming growth factor alpha [TGFα]). We have studied the effects of PGs and norepinephrine on DNA synthesis in serum‐free primary cultures of rat hepatocytes, and compared the PG effects with those of norepinephrine. PGE~2~, PGF~2α~, PGD~2~, and the synthetic analog dimethyl‐PGE~2~ markedly enhanced the DNA synthesis. A more quantitative analysis of the effects of PGE~2~ and PGF~2α~ on the DNA synthesis, in the presence and absence of EGF, indicated that these PGs interacted in an essentially multiplicative manner with the effect of EGF. The effects of PGE~2~ and PGF~2α~ showed almost complete additivity with the stimulation of DNA synthesis produced by maximally effective concentrations of norepinephrine. The data suggest (a) that PGE~2~ and PGF~2α~ facilitate and synergize with, rather than mediate, the actions of EGF in hepatocytes, and (b) that this effect of the PGs occurs by mechan

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Author

Magne Refsnes; G. Hege Thoresen; Olav F. Dajani; Thoralf Christoffersen

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0021-9541)

Published

1994

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)