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Transcriptome analysis by GeneTrail revealed regulation of functional categories in response to alterations of iron homeostasis in Arabidopsis thaliana by Mara Schuler; Andreas Keller; Christina Backes; Katrin Philippar; Hans-Peter Lenhof; Petra Bauer is a Agricultural and Biological Sciences article available to read on EtoBox.
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## Background High-throughput technologies have opened new avenues to study biological processes and pathways. The interpretation of the immense amount of data sets generated nowadays needs to be facilitated in order to enable biologists to identify complex gene networks and functional pathways. To cope with this task multiple computer-based programs have been developed. GeneTrail is a freely available online tool that screens comparative transcriptomic data for differentially regulated functional categories and biological pathways extracted from common data bases like KEGG, Gene Ontology (GO), TRANSPATH and TRANSFAC. Additionally, GeneTrail offers a feature that allows screening of individually defined biological categories that are relevant for the respective research topic. ## Results We have set up GeneTrail for the use of __Arabidopsis thaliana__. To test the functionality of this tool for plant analysis, we generated transcriptome data of root and leaf responses to Fe deficiency and the Arabidopsis metal homeostasis mutant __nas4x-1__. We performed Gene Set Enrichment Analysis (GSEA) with eight meaningful pairwise comparisons of transcriptome data sets. We were able to uncove
Who reads Transcriptome analysis by GeneTrail revealed regulation of functional categories in response to alterations of iron homeostasis in Arabidopsis thaliana?
It is typically read by researchers, students, and practitioners in Agricultural and Biological Sciences.
- Author
- Mara Schuler; Andreas Keller; Christina Backes; Katrin Philippar; Hans-Peter Lenhof; Petra Bauer
- Publisher
- BioMed Central; Springer (Biomed Central Ltd.); London: BioMed Central, 2001-; Springer Science and Business Media LLC; Society for Mining, Metallurgy and Exploration Inc. (ISSN 1471-2229)
- Published
- 2011
- Language
- EN
- Field
- Agricultural and Biological Sciences (Life Sciences)