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Can I read Heterogeneity of CTC contributes to the organotropism of breast cancer on EtoBox?
Heterogeneity of CTC contributes to the organotropism of breast cancer by Tao Yu; Cenzhu Wang; Mengyan Xie; Chengjun Zhu; Yongqian Shu; Jinhai Tang; Xiaoxiang Guan is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Heterogeneity of CTC contributes to the organotropism of breast cancer about?
Circulating tumor cells (CTCs) are viewed as pro-metastasis precursors shed from primary tumors or metastatic sites. The phenotypic and molecular heterogeneity of CTCs is associated with breast cancer progression and prognosis. Therefore, we divided CTCs into several subtypes according to their differences in biomarker status, epithelial/mesenchymal phenotype, aggregation status, and other factors to summarize their characteristics. Considering that the organ-specific metastasis is a hallmark of breast cancer, we adopted the "seed and soil" model to further analyze the relationship between the heterogeneity of CTCs and the organotropism of breast cancer. We speculated that CTCs might not only develop their genetic potential but communicate with surroundings, including chemokine systems, hemocytes, and extracellular matrix components, to regulate the organ-specific metastases of breast cancer.
Who reads Heterogeneity of CTC contributes to the organotropism of breast cancer?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Tao Yu; Cenzhu Wang; Mengyan Xie; Chengjun Zhu; Yongqian Shu; Jinhai Tang; Xiaoxiang Guan
- Publisher
- Elsevier BV
- Published
- 2021
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)