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PET imaging of tumor angiogenesis in mice with VEGF‐A–targeted ^86^Y‐CHX‐A′′‐DTPA‐bevacizumab by Tapan K. Nayak; Kayhan Garmestani; Kwamena E. Baidoo; Diane E. Milenic; Martin W. Brechbiel is a Medicine article available to read on EtoBox.
What is PET imaging of tumor angiogenesis in mice with VEGF‐A–targeted ^86^Y‐CHX‐A′′‐DTPA‐bevacizumab about?
## Abstract Bevacizumab is a humanized monoclonal antibody that binds to tumor‐secreted vascular endothelial growth factor (VEGF)‐A and inhibits tumor angiogenesis. In 2004, the antibody was approved by the US Food and Drug Administration (FDA) for the treatment of metastatic colorectal carcinoma in combination with chemotherapy. This report describes the preclinical evaluation of a radioimmunoconjugate, ^86^Y‐CHX‐A′′‐DTPA‐bevacizumab, for potential use in Positron Emission Tomography (PET) imaging of VEGF‐A tumor angiogenesis and as a surrogate marker for ^90^Y‐based radioimmunotherapy. Bevacizumab was conjugated to CHX‐A′′‐DTPA and radiolabeled with ^86^Y. __In vivo__ biodistribution and PET imaging studies were performed on mice bearing VEGF‐A–secreting human colorectal (LS‐174T), human ovarian (SKOV‐3) and VEGF‐A–negative human mesothelioma (MSTO‐211H) xenografts. Biodistribution and PET imaging studies demonstrated highly specific tumor uptake of the radioimmunoconjugate. In mice bearing VEGF‐A–secreting LS‐174T, SKOV‐3 and VEGF‐A–negative MSTO‐211H tumors, the tumor uptake at 3 days postinjection was 13.6 ± 1.5, 17.4 ± 1.7 and 6.8 ± 0.7 % ID/g, respectively. The corresponding
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- Author
- Tapan K. Nayak; Kayhan Garmestani; Kwamena E. Baidoo; Diane E. Milenic; Martin W. Brechbiel
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square; Test accounts (ISSN 0020-7136)
- Published
- 2010
- Language
- EN
- Field
- Medicine (Health Sciences)