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Plasma midregional proadrenomedullin (MR-proADM) concentrations and their biological determinants in a reference population by Magdalena Krintus; Marek Kozinski; Federica Braga; Jacek Kubica; Grazyna Sypniewska; Mauro Panteghini is a Medicine article available to read on EtoBox.
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## Abstract ## Background: Midregional proadrenomedullin (MR-proADM) is emerging as a prognostic biomarker for detecting the failure of multiple organs. Establishment of scientifically robust reference intervals facilitates interpretation of laboratory test results. The objectives of this study were (i) to establish reliable reference intervals for plasma MR-proADM using a commercially available automated fluoroimmunoassay in apparently healthy individuals, and (ii) to identify biological determinants of MR-proADM concentrations. ## Methods: A total of 506 questionnaire-identified apparently healthy adults were enrolled in a single-center, cross-sectional study. A final reference group (n=172) was selected after exclusion of obese individuals, those with increased values of laboratory biomarkers indicating asymptomatic myocardial injury or dysfunction, ongoing inflammation, diabetes, dyslipidemia and renal dysfunction and outliers. ## Results: The 2.5th and 97.5th percentile intervals for MR-proADM values in the reference group (90% confidence interval) were 0.21 (0.19–0.23) and 0.57 (0.55–0.59) nmol/L, respectively. Although older age, higher values of HbA~1c~, C-reactive protein,
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- Author
- Magdalena Krintus; Marek Kozinski; Federica Braga; Jacek Kubica; Grazyna Sypniewska; Mauro Panteghini
- Publisher
- Walter de Gruyter GmbH
- Published
- 2018
- Language
- EN
- Field
- Medicine (Health Sciences)