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Strain Variation in the Mycobacterium tuberculosis Complex: Its Role in Biology, Epidemiology and Control Volume 1019 by Gagneux, Sebastien is a scholarly article available to read on EtoBox.

What is Strain Variation in the Mycobacterium tuberculosis Complex: Its Role in Biology, Epidemiology and Control Volume 1019 about?

Until about 10 years ago, the general view in the field was that Mycobacterium tuberculosis , the causative agent of human tuberculosis was a "clone" with insufficient natural sequence variation between clinical strains to be considered biologically and epidemiologically "relevant". This view has now changed quite dramatically thanks to the –omics revolution, particularly the advent of next generation DNA sequencing. Large-scale comparative genomic studies over the last few years have revealed that M. tuberculosis clinical strains are more genetically diverse than appreciated previously. Moreover, an increasing number of experimental and epidemiological studies are showing that this genetic diversity also translates into important phenotypic variation. Taken together, these findings have led to a paradigm shift, such that currently phylogenetic diversity among M. tuberculosis clinical strains is being considered in the development of new tools to combat tuberculosis. The purpose of this book is to bring together a series of contributions from some of the most influential groups working on various aspects of M. tuberculosis diversity, and which through their work have contrib

Author

Gagneux, Sebastien

Publisher

Springer International Publishing : Imprint : Springer

Published

2017

Language

EN

ISBN

9783319643694