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Proton pump inhibitor use and risk for recurrent Clostridioides difficile infection: a systematic review and meta-analysis by Kristin M. D'Silva; Raaj Mehta; Michael Mitchell; Todd C. Lee; Vibha Singhal; Marnie Goodwin Wilson; Emily G. McDonald is a Medicine article available to read on EtoBox.

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## Objectives: Proton pump inhibitor (ppi) therapy is a potentially modifiable risk factor for recurrent clostridioides difficile infection (cdi). citing an absence of clinical trials, many guidelines do not provide recommendations for addressing ppi management. our aim was to perform an updated systematic review and meta-analysis evaluating the association between ppi use and recurrent cdi addressing prior methodological limitations. ## Methods: Data sources were medline and embase. eligible studies were cohort and case-control studies; there were no restrictions on study setting or duration of follow-up. participants were adults with prior cdi who did or did not receive ppi therapy and were assessed for recurrent cdi. summary (unadjusted) odds ratios (ors) and 95% confidence intervals (cis) were calculated using a random effects model. prespecified subgroup analyses were performed to explore heterogeneity including study design, study quality, duration of follow-up, adjustment for confounders, and outcome definition. ## Results: Sixteen studies were included in the meta-analysis, comprising 57 477 patients with cdi, of whom 6870 (12%) received ppis. the rate of recurrent cdi was

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Author

Kristin M. D'Silva; Raaj Mehta; Michael Mitchell; Todd C. Lee; Vibha Singhal; Marnie Goodwin Wilson; Emily G. McDonald

Publisher

Elsevier BV

Published

2021

Language

EN

Field

Medicine (Health Sciences)