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Development of Amylopectin Based Polyurethanes for Sustained Drug Release Studies by Muhammad Asif Javaid; Sobia Jabeen; Noureen Arshad; Khalid Mahmood Zia; Muhammad Tahir Hussain; Ijaz Ahmed Bhatti; Amer Iqbal; Saliha Ahmad; Inam Ullah is a Materials Science article available to read on EtoBox.
What is Development of Amylopectin Based Polyurethanes for Sustained Drug Release Studies about?
In this research work, the crosslinked structure of polyurethane has been exploited for sustained drug delivery. Polyurethane composites have been prepared by the reaction of isophorone diisocyanate (IPDI) and polycaprolactone diol (PCL), which were further extended by varying the mole ratios of amylopectin (AMP) and 1,4butane diol (1,4-BDO) chain extenders. The progress and completion of the reaction of polyurethane (PU) were confirmed using Fourier Transform infrared (FTIR) and nuclear magnetic resonance ( 1 H NMR) spectroscopic techniques. Gel permeation chromatography (GPC) analysis showed that the molecular weights of prepared polymers were increased with the addition of amylopectin into the PU matrix. The molecular weight of AS-4 (M w ≈ 99,367) was found threefold as compared to amylopectin-free PU (M w ≈ 37,968). Thermal degradation analysis was done using thermal gravimetric analysis (TGA) and inferred that AS-5 showed stability up to 600 • C which was the maximum among all PUs because AMP has a large number of -OH units for linking with prepolymer resulting in a more cross-linked structure which improved the thermal stability of the AS-5 sample. The samples prepared with A
Who reads Development of Amylopectin Based Polyurethanes for Sustained Drug Release Studies?
It is typically read by researchers, students, and practitioners in Materials Science.
- Author
- Muhammad Asif Javaid; Sobia Jabeen; Noureen Arshad; Khalid Mahmood Zia; Muhammad Tahir Hussain; Ijaz Ahmed Bhatti; Amer Iqbal; Saliha Ahmad; Inam Ullah
- Publisher
- Elsevier BV
- Published
- 2023
- Language
- EN
- Field
- Materials Science (Physical Sciences)