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The Spectrum of Cerebrovascular Disease and Associated Cognitive Decline by Victoria J. Williams; Steven E. Arnold; David H. Salat is a book available to read on EtoBox.

What is The Spectrum of Cerebrovascular Disease and Associated Cognitive Decline about?

Throughout the lifespan, common variations in systemic health and illness contribute to alterations in vasculature structure and function throughout the body, significantly increasing risk for cardiovascular and cerebrovascular disease (CVD). CVD is a prevalent cause of mortality in late life; it also promotes brain alterations, contributing to cognitive decline and, when severe, vascular dementia. Even prior to diseased states, individual variation in CVD risk is associated with structural and functional brain alterations. Yet, how cumulative asymptomatic alterations in vessel structure and function contribute to more subtle changes in brain tissue integrity and function that emerge in late life is unclear. Finally, vascular risk factors are associated with the clinical progression of neurodegenerative diseases such as Alzheimer’s disease (AD); however, recent theory posits that vascular degeneration may serve a contributory role in these conditions. This chapter reviews how lifespan changes in vascular health contribute to degenerative changes in neural tissue and the subsequent development of cognitive impairment and/or vascular dementia. It first discusses associations between

Author

Victoria J. Williams; Steven E. Arnold; David H. Salat

Publisher

Oxford University Press

Published

2019

Language

EN