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Can I read DNA Topoisomerase I—Targeted Chemotherapy of Human Colon Cancer in Xenografts on EtoBox?
DNA Topoisomerase I—Targeted Chemotherapy of Human Colon Cancer in Xenografts by Beppino C. Giovanella; John S. Stehlin; Monroe E. Wall; Mansukh C. Wani; Allan W. Nicholas; Leroy F. Liu; Robert Silber; Milan Potmesil is a Medicine article available to read on EtoBox.
What is DNA Topoisomerase I—Targeted Chemotherapy of Human Colon Cancer in Xenografts about?
Drug development is needed to improve chemotherapy of patients with locally advanced or metastatic colon carcinoma, who otherwise have an unfavorable prognosis. DNA topoisomerase I, a nuclear enzyme important for solving topological problems arising during DNA replication and for other cellular functions, has been identified as a principal target of a plant alkaloid 20(S)-camptothecin. Significantly increased concentrations of this enzyme, compared to that in normal colonic mucosa, were found in advanced stages of human colon adenocarcinoma and in xenografts of colon cancer carried by immunodeficient mice. Several synthetic analogs of camptothecin, selected by tests with the purified enzyme and tissue-culture screens, were evaluated in the xenograft model. Unlike other anticancer drugs tested, 20(RS)-9-amino-camptothecin (9-AC) induced disease-free remissions. The overall drug toxicity was low and allowed for repeated courses of treatment.
Who reads DNA Topoisomerase I—Targeted Chemotherapy of Human Colon Cancer in Xenografts?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Beppino C. Giovanella; John S. Stehlin; Monroe E. Wall; Mansukh C. Wani; Allan W. Nicholas; Leroy F. Liu; Robert Silber; Milan Potmesil
- Published
- 1989
- Language
- EN
- Field
- Medicine (Social Sciences)