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Jaspolide B Induces Apoptosis in Hepatoma by Walid Ebid Elgammal is a document available to read on EtoBox.
1. The study investigated the effects of jaspolide B, a novel isomalabaricane-type triterpene isolated from the marine sponge Jaspis sp., on human hepatoma cells. 2. Jaspolide B inhibited the growth of Bel-7402 and HepG2 hepatoma cells with IC50 values of 29.1 and 29.5 μM, respectively. 3. Jaspolide B induced apoptosis in up to 66.8% of Bel-7402 cells over 48 hours of incubation, as confirmed by enhanced mitochondrial masses, cell membrane permeability, and nuclear condensation. It also arrested the cel
- Author
- Walid Ebid Elgammal
- Language
- EN