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Progressive dementia associated with ataxia or obesity in patients with Tropheryma whipplei encephalitis by Florence Fenollar; François Nicoli; Claire Paquet; Hubert Lepidi; Patrick Cozzone; Jean-Christophe Antoine; Jean Pouget; Didier Raoult is a Medicine article available to read on EtoBox.
What is Progressive dementia associated with ataxia or obesity in patients with Tropheryma whipplei encephalitis about?
## Background __Tropheryma whipplei__, the agent of Whipple's disease, causes localised infections in the absence of histological digestive involvement. Our objective is to describe __T. whipplei__ encephalitis. ## Methods We first diagnosed a patient presenting dementia and obesity whose brain biopsy and cerebrospinal fluid specimens contained __T. whipplei__ DNA and who responded dramatically to antibiotic treatment. We subsequently tested cerebrospinal fluid specimens and brain biopsies sent to our laboratory using __T. whipplei__ PCR assays. PAS-staining and __T. whipplei__ immunohistochemistry were also performed on brain biopsies. Analysis was conducted for 824 cerebrospinal fluid specimens and 16 brain biopsies. ## Results We diagnosed seven patients with __T. whipplei__ encephalitis who demonstrated no digestive involvement. Detailed clinical histories were available for 5 of them. Regular PCR that targeted a monocopy sequence, PAS-staining and immunohistochemistry were negative; however, several highly sensitive and specific PCR assays targeting a repeated sequence were positive. Cognitive impairments and ataxia were the most common neurologic manifestations. Weight gain w
Who reads Progressive dementia associated with ataxia or obesity in patients with Tropheryma whipplei encephalitis?
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- Author
- Florence Fenollar; François Nicoli; Claire Paquet; Hubert Lepidi; Patrick Cozzone; Jean-Christophe Antoine; Jean Pouget; Didier Raoult
- Publisher
- BioMed Central; Springer (Biomed Central Ltd.); London: BioMed Central, 2001-; Springer Science and Business Media LLC; Society for Mining, Metallurgy and Exploration Inc. (ISSN 1471-2334)
- Published
- 2011
- Language
- EN
- Field
- Medicine (Health Sciences)