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Degradation, cytotoxicity, and biocompatibility of NIPAAm‐based thermosensitive, injectable, and bioresorbable polymer hydrogels by Zhanwu Cui; Bae Hoon Lee; Christine Pauken; Brent L. Vernon is a Engineering article available to read on EtoBox.

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## Abstract A thermosensitive, injectable, and bioresorbable polymer hydrogel, poly(N‐isopropylacrylamide‐co‐dimethyl‐γ‐butyrolactone acrylate‐co‐acrylic acid) [poly(NDBA)], was synthesized by radical copolymerization with 7.00 mol % dimethyl‐γ‐butyrolactone acrylate in tetrahydrofuran. The chemical composition was determined by acid titration in conjunction with ^1^H NMR quantification. The molecular weight and polydispersity were determined by gel permeation chromatography in conjunction with static light scattering. The degradation properties of the polymer hydrogel were characterized using differential scanning calorimetry, percentage mass loss, cloud point test, and swelling ratio over time. It was found that the initial lower critical solution temperature (LCST) of the polymer is between room temperature and body temperature and that it takes about 2 weeks for the LCST to surpass body temperature under physiological conditions. An indirect cytotoxicity test indicated that this copolymer has relatively low cytotoxicity as seen with 3T3 fibroblast cells. The __in vivo__‐gelation and degradation study showed good agreement with __in vitro__‐degradation findings, and no detriment

Who reads Degradation, cytotoxicity, and biocompatibility of NIPAAm‐based thermosensitive, injectable, and bioresorbable polymer hydrogels?

Author

Zhanwu Cui; Bae Hoon Lee; Christine Pauken; Brent L. Vernon

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 1549-3296)

Published

2011

Language

EN

Field

Engineering (Physical Sciences)