Opening book details…
Can I read The neural correlates of naming and fluency deficits in Alzheimer's disease: an FDG‐PET study on EtoBox?
The neural correlates of naming and fluency deficits in Alzheimer's disease: an FDG‐PET study by Rebecca J. Melrose; Olivia M. Campa; Dylan G. Harwood; Sheryl Osato; Mark A. Mandelkern; David L. Sultzer is a Medicine article available to read on EtoBox.
What is The neural correlates of naming and fluency deficits in Alzheimer's disease: an FDG‐PET study about?
## Abstract ## Objective To examine the neural processes associated with language deficits in Alzheimer's disease (AD), and in particular to elucidate the correlates of confrontation naming and word retrieval impairments. ## Methods Sixty patients with probable AD were included. Confrontation naming was assessed using the number of words spontaneously named correctly on the Boston Naming Test. We recorded the number of additional words stated following phonemic cuing. We also assessed phonemic (FAS) and semantic (supermarket items) fluency. We then correlated performance on each measure with resting cortical metabolic activity using FDG‐PET images. ## Results We found that poorer ability to spontaneously name an object was associated with hypometabolism of bilateral inferior temporal lobes. In contrast, when a phonemic cue was provided, successful naming under this condition was associated with higher metabolic activity in bilateral inferior frontal gyrus (IFG), right superior frontal gyrus (SFG), left temporal, and occipital regions. Consistent with these findings, we found that poorer semantic fluency was associated with hypometabolism in regions including both IFG and temporal r
Who reads The neural correlates of naming and fluency deficits in Alzheimer's disease: an FDG‐PET study?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Rebecca J. Melrose; Olivia M. Campa; Dylan G. Harwood; Sheryl Osato; Mark A. Mandelkern; David L. Sultzer
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square (ISSN 0885-6230)
- Published
- 2009
- Language
- EN
- Field
- Medicine (Health Sciences)