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Function and regulation of UDP-glucuronosyltransferase genes in health and liver disease: Report of the seventh international workshop on glucuronidation, september 1993, Pitlochry, Scotland by Brian Burchell B.Sc. Ph.D. MCRPath.; Michael W. H. Coughtrie; Peter L. M. Jansen is a Medicine article available to read on EtoBox.

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opening address insight into the history of glucuronidation, in particular the discovery of the nucleotide sugar, UDPGA. He also expressed as his opinion that many questions that have captivated researchers in this field for decades will be resolved before the turn of the century. However, this workshop showed that this is not yet the case; some of the time-honored questions remain resistant even to the new molecular techniques. ## BACKGROUND UGT catalyzes the conjugation of foreign and endogenous substrates (aglycones) with D-glucuronic acid. UDPGA serves as the donor substrate of the conjugating sugar. This is illustrated in the following equation. UDPGA + ROH+RO-glucuronic acid k UDP In addition to ROH, glucuronidation of RCOOH, RSH and RNH occurs thus forming ether, ester, thiol and amide glucuronides. UDPGA is synthesized from UDP-glucose by the cytosolic enzyme UDP-glucose dehydrogenase. UGT is localized in the membranes of the ER and the nuclear envelope of hepatocytes, renal tubular cells, intestine, lung, adrenals and various other tissues. Glucuronidation makes lipophilic aglycones more water soluble so that they can be secreted in the urine or bile. In general, glucuroni

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Author

Brian Burchell B.Sc. Ph.D. MCRPath.; Michael W. H. Coughtrie; Peter L. M. Jansen

Publisher

Ovid Technologies (Wolters Kluwer Health)

Published

1994

Language

EN

Field

Medicine (Health Sciences)