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Classical sickle beta-globin haplotypes exhibit a high degree of long-range haplotype similarity in African and Afro-Caribbean populations by Neil Hanchard; Abier Elzein; Clare Trafford; Kirk Rockett; Margaret Pinder; Muminatou Jallow; Rosalind Harding; Dominic Kwiatkowski; Colin McKenzie is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
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## Background The sickle (β^s^) mutation in the __beta-globin__ gene (HBB) occurs on five "classical" β^s^ haplotype backgrounds in ethnic groups of African ancestry. Strong selection in favour of the β^s^ allele – a consequence of protection from severe malarial infection afforded by heterozygotes – has been associated with a high degree of extended haplotype similarity. The relationship between classical β^s^ haplotypes and long-range haplotype similarity may have both anthropological and clinical implications, but to date has not been explored. Here we evaluate the haplotype similarity of classical β^s^ haplotypes over 400 kb in population samples from Jamaica, The Gambia, and among the Yoruba of Nigeria (Hapmap YRI). ## Results The most common β^s^ sub-haplotype among Jamaicans and the Yoruba was the Benin haplotype, while in The Gambia the Senegal haplotype was observed most commonly. Both subtypes exhibited a high degree of long-range haplotype similarity extending across approximately 400 kb in all three populations. This long-range similarity was significantly greater than that seen for other haplotypes sampled in these populations (P < 0.001), and was independent of marker
Who reads Classical sickle beta-globin haplotypes exhibit a high degree of long-range haplotype similarity in African and Afro-Caribbean populations?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Neil Hanchard; Abier Elzein; Clare Trafford; Kirk Rockett; Margaret Pinder; Muminatou Jallow; Rosalind Harding; Dominic Kwiatkowski; Colin McKenzie
- Publisher
- BioMed Central; Springer (Biomed Central Ltd.); London: BioMed Central, 2000-; Springer Science and Business Media LLC (ISSN 1471-2156)
- Published
- 2007
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)