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This study compares the effectiveness of isoamyl nitrite and sodium nitrite as antidotes for acute cyanide poisoning in mice. Results indicate that sodium nitrite, particularly when administered as an aerosol, is more effective than isoamyl nitrite, which produced toxic effects due to isoamyl alcohol. Additionally, anesthesia was found to prolong survival but also negated the antidotal effects of nitrite, highlighting important considerations for testing cyanide antidotes in anesthetized subjects.

Author

ajaysr0304

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EN