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Can I read The Use of Gel Electrophoresis to Study the Reactions of Activated Amino Acids with Oligonucleotides on EtoBox?
The Use of Gel Electrophoresis to Study the Reactions of Activated Amino Acids with Oligonucleotides by Gerhard Zieboll; Leslie E. Orgel is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is The Use of Gel Electrophoresis to Study the Reactions of Activated Amino Acids with Oligonucleotides about?
We have used gel electrophoresis to study the primary covalent addition of amino acids to oligonucleotides or their analogs and the subsequent addition of further molecules of the amino acids to generate peptides covalently linked to the oligonucleotides. We have surveyed the reactions of a variety of amino acids with the phosphoramidates derived from oligonucleotide 5'-phosphates and ethylenediamine. We find that arginine and amino acids that can interact with oligonucleotides through stacking interactions react most efficiently. D- and L-amino acids give indistinguishable families of products.
Who reads The Use of Gel Electrophoresis to Study the Reactions of Activated Amino Acids with Oligonucleotides?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Gerhard Zieboll; Leslie E. Orgel
- Publisher
- Springer; Springer-Verlag; Springer Verlag; Springer Science and Business Media LLC (ISSN 0022-2844)
- Published
- 1993
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)