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Targeted Blood Metabolomic Study on Retinopathy of Prematurity by Yuhang Yang; Zhenquan Wu; Sitao Li; Mingmin Yang; Xin Xiao; Chaohui Lian; Wei Wen; Honghui He; Jian Zeng; Jiantao Wang; Guoming Zhang is a Medicine article available to read on EtoBox.

What is Targeted Blood Metabolomic Study on Retinopathy of Prematurity about?

## Purpose This study aims at exploring alterations of major metabolites and metabolic pathways in retinopathy of prematurity (ROP) infants and identifying biomarkers that may merit early diagnosis of ROP. ## Methods We analyzed targeted metabolites from 81 premature infants (<34 weeks of gestational age), including 40 ROP cases (15 males and 25 females, birth weight 1.263 ± 0. 345 kg, gestational age 31.20 ± 4.62 weeks) and 41 cases (30 males, 11 females, birth weight 1.220 ± 0.293 kg, gestational age 30.96 ± 4.17 weeks) of well-matched non-ROP controls. Metabolites were measured by ultra-performance liquid chromatography-tandem mass spectrometry. Standard multivariate and univariate analysis was performed to interpret metabolomic results. ## Results Glycine, glutamate, leucine, serine, piperidine, valine, tryptophan, citrulline, malonyl carnitine (C3DC), and homocysteine were identified as the top discriminant metabolites. In particular, discriminant concentrations of C3DC and glycine were also confirmed by univariate analysis as statistically significant different between ROP and non-ROP infants. ## Conclusions This study gained an insight into the metabolomic aspects of ROP dev

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Author

Yuhang Yang; Zhenquan Wu; Sitao Li; Mingmin Yang; Xin Xiao; Chaohui Lian; Wei Wen; Honghui He; Jian Zeng; Jiantao Wang; Guoming Zhang

Publisher

Association for Research in Vision and Ophthalmology (ARVO)

Published

2020

Language

EN

Field

Medicine (Health Sciences)