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Circadian clock protein BMAL1 broadly influences autophagy and endolysosomal function in astrocytes by Celia A. McKee; Alexander J. Polino; Melvin W. King; Erik S. Musiek is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Circadian clock protein BMAL1 broadly influences autophagy and endolysosomal function in astrocytes about?

## Significance The molecular circadian clock regulates daily rhythms in gene expression, cellular function, and animal behavior. Clock proteins can also regulate noncircadian functions that are highly cell-type specific. Regulation of proteostasis in different cell types in the brain to remove misfolded proteins is critical for healthy brain aging. However, the role of clock proteins in the control of degradation pathways has been poorly investigated in the brain. Here, we demonstrate that deletion of the core clock protein BMAL1 leads to increased astrocyte endolysosomal function and extracellular protein degradation. Our findings implicate BMAL1 in astrocyte proteostasis and brain health.

Who reads Circadian clock protein BMAL1 broadly influences autophagy and endolysosomal function in astrocytes?

Author

Celia A. McKee; Alexander J. Polino; Melvin W. King; Erik S. Musiek

Publisher

Proceedings of the National Academy of Sciences

Published

2023

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)