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CELA2A mutations were found to predispose individuals to early-onset atherosclerosis and metabolic syndrome. The paper explores the effects of CELA2A mutations through in vitro and in vivo studies. They found that CELA2A regulates insulin levels and restrains platelet activation. Mutations in CELA2A were associated with higher insulin and platelet activation compared to wild-type CELA2A. The findings suggest CELA2A acts as an insulinotropic peptide and limits platelet activation through proteolytic degradat

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api-505989771

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