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The Fate of Soft Callus Chondrocytes During Long Bone Fracture Repair by Joanna L. Ford; Derek E. Robinson; Brigitte E. Scammell is a Medicine article available to read on EtoBox.

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## Abstract Following fracture, the cartilaginous tissue of the soft callus is eventually replaced by bone. Removal of the cartilage is a critical part of the bone healing process but information concerning the changes in chondrocytes during this process is sparse. The aim of the study was to investigate the fate of chondrocytes in the soft callus during the bone repair process using a rabbit tibial fracture model. Fracture tissue was processed for collagen I‐III and keratan sulphate immunohistochemistry to study changes in matrix composition and the TUNEL technique (terminal deoxynucleotidyl transferase medicated dUTP nick‐end labelling) to identify death of soft callus chondrocytes. Transmission electron microscopy (TEM) was also carried out to investigate the ultrastructure of chondrocytes within the soft callus. Results showed that the size of the cartilage area decreased over time and that cartilage matrix was replaced with new matrix rich in collagen I and III. Chondrocytes became engulfed in the new matrix and appeared to stop producing cartilage matrix. Chondrocyte cell death was seen at the border of the soft callus, just within the newly produced matrix. TEM revealed that

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Author

Joanna L. Ford; Derek E. Robinson; Brigitte E. Scammell

Publisher

Elsevier Science; Wiley (John Wiley & Sons); Wiley-Blackwell; Wiley (ISSN 0736-0266)

Published

2003

Language

EN

Field

Medicine (Health Sciences)