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Acidic Fibroblast Growth Factor Modulates Gene Expression in the Rat Thyroid in Vivo by Jean-Pierre Chanoine; Lewis E. Braverman; William J. DeVito; Gary S. Stein; Victoria Shalhoub; Jane B. Lian; Chris A. Huber is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
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## Abstract We have recently demonstrated that the iv administration of acidic fibroblast growth factor(a‐FGF) to rats for 6 days results in a marked increase in thyroid weight colloid accumulation and flat, quiescent follicular cells. Whereas a‐FGF administration consistently increases thyroid weight, there are only minor alterations in serum TSH and thyroid hormones, and no change in intrathyroidal metabolism of ^125^l metabolism. In the present work, we studied the effects of 1 or 6 daily injections of a‐FGF (60 μ/kg BW) or vehicle on the mRNA levels for histone, c‐fos, actin, type I 5′ deiodinase (5′D‐1), thyroid peroxidase, and thyroglobulin and cathepsin D in the thyroid, liver and bone. Rats were sacrificed 0.5, 2, 4, 8 and 24 h after the 1st or the 6th a‐FGF injection and thyroid, liver and calvarium were removed. The relative amounts of mRNAs were determined by slot blot analysis. There was a 43% increase in thyroid weight in rats treated with a‐FGF for 6 days compared to vehicle‐treated rats. We observed an increase in c‐fos mRNA content in the thyroid gland 0.5 to 4 h after 1 or 6 injections of a‐FGF. In contrast, treatment with a‐FGF for 1 or 6 days did not affect histo
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It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Jean-Pierre Chanoine; Lewis E. Braverman; William J. DeVito; Gary S. Stein; Victoria Shalhoub; Jane B. Lian; Chris A. Huber
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0730-2312)
- Published
- 1992
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)