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Can I read Segregation analysis of leprosy in families of northern Thailand: Familial Leprosy in Northern Thailand on EtoBox?
Segregation analysis of leprosy in families of northern Thailand: Familial Leprosy in Northern Thailand by Dr. Diane K. Wagener; Victoria Schauf; Kenrad E. Nelson; David Scollard; Arthur Brown; Trevor Smith; Ingrid B. Borecki is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Segregation analysis of leprosy in families of northern Thailand: Familial Leprosy in Northern Thailand about?
Sixty-three families with multiple instances of leprosy were identified through a major leprosy treatment center in northern Thailand. Complex segregation analyses for single major genes or polygenic inheritance were performed using the maximum-likelihood routine POINTER to determine the most likely etiologic model of genetic susceptibility. Liability differences between men and women were considered in these models. When individuals were considered to be affected because they had any form of leprosy, a generalized major gene model with nearly dominant parameters on the liability scale, but additive penetrances, was found to be the most likely. When only those individuals who had tuberculoid forms of leprosy were considered to be affected, a recessive model was found to be the most likely; however, the discrimination between various models was poor. Further analyses are necessary to delineate genetic mechanisms to explain these apparently divergent results. In particular, methods of testing two locus models should be considered.
Who reads Segregation analysis of leprosy in families of northern Thailand: Familial Leprosy in Northern Thailand?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Dr. Diane K. Wagener; Victoria Schauf; Kenrad E. Nelson; David Scollard; Arthur Brown; Trevor Smith; Ingrid B. Borecki
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0741-0395)
- Published
- 1987
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)